NR (Nicotinamide Riboside) and NMN (Nicotinamide Mononucleotide)
It was initially thought that NAD+ molecules were too large to be absorbed directly. Recently, it was found that NAD+ can cross the blood-brain barrier and reach the hypothalamus when ingested sublingually (under the tongue). It can increase the levels of NAD+ in this gland, which is beneficial for the entire body as it controls metabolism. It can also be a possible supplement to help those who have metabolic disorders because of decreased NAD+ levels in the hypothalamus.
NMN, on the other hand, increases NAD+ levels in cells throughout the whole body and is a better nutritional supplement for increasing overall NAD + levels and slowing down ageing.
Molecularly, NMN looks more like NAD+ than NR, it is further down the production pathway, closer to NAD+, which is what our body uses.
Studies have shown many great benefits of NMN on ageing mechanisms. Similar results are not as impressive for NR.
Many well-known ageing experts and doctors use NMN, which, while not conclusive evidence, suggests that it gets better results than NR. Avea is always on the leading edge of scientific research, so if for any reason NR eventually proves to be more effective than NMN, we will gladly change our minds and our supplements. Until then, the variety of evidence suggests that NMN is more effective at targeting the hallmarks of ageing.