Thousands of people have taken NMN in reasonable doses (usually 125 mg to 1 g) over the years without problems, and its safety has been confirmed by more than scientific studies.
- The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial (2023): Walking distance increase during the six-minute walking test was statistically significantly higher in the 300 mg, 600 mg, and 900 mg groups compared to placebo at both days 30 and 60 (all p < 0.01), with longest walking distances measured in the 600 mg and 900 mg groups. The blood biological age increased significantly in the placebo group and stayed unchanged in all NMN-treated groups at day 60, which resulted in a significant difference between the treated groups and placebo (all p < 0.05) https://pubmed.ncbi.nlm.nih.gov/36482258/
- Safety of NMN supplementation up to 1.25 g/day with no adverse effects https://rdcu.be/c4gpB
- Safety of NMN intake, pharmacokinetics and positive effect on blood glucose: https://www.jstage.jst.go.jp/article/endocrj/67/2/67_EJ19-0313/_pdf/-char/en
- NAD+levels are significantly increased / safety of NMN: https://www.frontiersin.org/articles/10.3389/fnut.2022.868640/full
- NMN increases insulin sensitivity in prediabetic women: https://pubmed.ncbi.nlm.nih.gov/33888596/
- NAD+ increase with supplementation: https://www.frontiersin.org/articles/10.3389/fragi.2022.851698/full
- Improved muscle strength and performance: https://www.researchsquare.com/article/rs-455083/v1
- NMN supplementation increases blood NAD concentrations and is safe and well tolerated when taken orally up to 900 mg NMN daily / improves physical performance: https://link.springer.com/article/10.1007/s11357-022-00705-1
- Improves aerobic capacity in amateur runners https://jissn.biomedcentral.com/articles/10.1186/s12970-021-00442-4
- Potential of NMN to prevent loss of physical capacity and improve fatigue in older adults https://www.mdpi.com/2072-6643/14/4/755
- Meta-analysis - has a significant positive effect on patients with cardiovascular disease and dyslipidaemia https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-022-00653-9
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